Bacterial Adaptation during Chronic Respiratory Infections

Bacterial Adaptation during Chronic Respiratory Infections

Chronic lung infections are associated with increased morbidity and mortality for individuals with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The process of chronic colonisation allows pathogens to adapt over time to cope with changing selection pressures, co-infecting species and antimicrobial therapies. These adaptations ca...

Dark adaptation during systemic hypoxia induced by chronic respiratory insufficiency.

PURPOSE To investigate dark adaptation during hypoxia in patients with chronic respiratory failure. METHODS At three visits, dark adaptation was recorded by computerized dark adaptometry in 13 patients with chronic respiratory insufficiency treated by long-term oxygen therapy. At visits 1 and 3, the patients were administered their usual oxygen supplement. At visit 2, no oxygen was given. At ...

Mucosal immunization for bacterial respiratory infections.

Bacterial Respiratory Infections Complicating Human Immunodeficiency Virus.

Opportunistic bacterial and fungal infections of the lower respiratory tract, most commonly those caused by Streptococcus pneumoniae (the pneumococcus), Mycobacterium tuberculosis, and Pneumocystis jirovecii, remain the major causes of mortality in those infected with human immunodeficiency virus (HIV). Bacterial respiratory pathogens most prevalent in those infected with HIV, other than M. tub...

Intrafamilial contagion in chronic sino-respiratory infections.

The problem of chronic sino-respiratory infections which includes sinusitis, bronchitis, bronchiectasis and infective asthma is of great magnitude. Although these illnesses do not immediately endanger the life of the patient they seriously affect the health of many individuals. I t is estimated that approximately 2,000,000 people in this country suffer from chronic bronchitis and 1,250,000 from...